Pharmacokinetics of propofol in 10 to 15 days old foals

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Published: Dec 29, 2000
DOI: https://doi.org/10.4067/S0301-732X2000000200006
Keywords:
- pharmacokinetic
- propofol
- foals

Main Article Content

E. BARONI
Cátedra de Farmacología, Fac. de Agron. y Veterinaria, Universidad Nacional del Litoral, Argentina.
F. AHUMADA
Instituto de Farmacología, Fac. de Ciencias Veterinarias, Universidad Austral de Chile, Valdivia, Chile.
C. LÜDERS
Escuela de Cs. Veterinarias, Fac. de Acuicultura. y Cs. Veterinarias, Univ. Católica de Temuco, Temuco, Chile.
I. SAAVEDRA
Dpto. de Bioquímica, Fac. de Medicina, Univ. de Chile, Santiago, Chile.
R. ZAMBUCETTI
Dpto. de Bioquímica, Fac. de Medicina, Univ. de Chile, Santiago, Chile.

Abstract

Pharmacokinetic variables of propofol were studied in 8 foals. Plasma levels of propofol at different time after a single intravenous dose of 2.4 mg/kg bw, were determined by HPLC. An open two compartments model was used to evaluate plasma levels of propofol and values of t1/2a, t1/2b , Vdc, Vdss, Vdb, Cltotal y MRT were obtained. Propofol pharmacokinetic disposition showed a rapid distribution and removal from organic tissues, and the reported pharmacokinetic variables contribute to determine the appropriate dose to be given .

Article Details

How to Cite
BARONI, E., AHUMADA, F., LÜDERS, C., SAAVEDRA, I., & ZAMBUCETTI, R. (2000). Pharmacokinetics of propofol in 10 to 15 days old foals. Archivos De Medicina Veterinaria, 32(2), 193–200. https://doi.org/10.4067/S0301-732X2000000200006
Issue
Vol. 32 No. 2 (2000)
Section
ARTÍCULOS ORIGINALES
Author Biographies

E. BARONI, Cátedra de Farmacología, Fac. de Agron. y Veterinaria, Universidad Nacional del Litoral, Argentina.

M.V., M.Sc.

F. AHUMADA, Instituto de Farmacología, Fac. de Ciencias Veterinarias, Universidad Austral de Chile, Valdivia, Chile.

M.V. Dr. med. vet.

C. LÜDERS, Escuela de Cs. Veterinarias, Fac. de Acuicultura. y Cs. Veterinarias, Univ. Católica de Temuco, Temuco, Chile.

M.V., M.Sc.

I. SAAVEDRA, Dpto. de Bioquímica, Fac. de Medicina, Univ. de Chile, Santiago, Chile.

Q.F.

R. ZAMBUCETTI, Dpto. de Bioquímica, Fac. de Medicina, Univ. de Chile, Santiago, Chile.

Q.F.